Inflammation and Metastasis

This book, now in a thoroughly revised and updated second edition, provides the latest information on cancer metastasis from the perspective of inflammation and presents new ideas on the complicated mechanisms of metastasis and potential ...

Inflammation and Metastasis

Inflammation and Metastasis

This book, now in a thoroughly revised and updated second edition, provides the latest information on cancer metastasis from the perspective of inflammation and presents new ideas on the complicated mechanisms of metastasis and potential therapeutic targets. Key features include discussion of mechanisms recently identified to be involved in the resolution phase of inflammation, presentation of the latest evidence regarding the roles of endogenous TLR4 ligands in metastasis, and thorough explanation of the concept of homeostatic inflammation and current understanding of the significance of its dysregulation for metastasis. Structure-based thinking is another important element of the book, and it is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, at the center of which cancer is located. Examples of the many additional specific topics covered in this edition include the functional involvement of new types of RNA in cancer, the insights offered by recent advances in bioinformatics, and the potential of a casein kinase 1α inhibitor in the treatment of acute myeloid leukemia. The book will be a valuable update and resource for both experienced and younger researchers. Homeostasis, originated from an idea of internal milieu by Claude Bernard, is eventually maintained by endogenous elements. The essential features of inflammation are leukocyte mobilization and increased vascular permeability, which could take place in many homeostatic or physiological conditions at low levels. Homeostatic inflammation is a concept to explain pathological settings such as metastasis in which irrespective of its level those inflammatory features are misused with endogenous molecules (see Chap. 14,15). As inflammation comprises many biological fields, targeting a single molecule for a disease could potentially make a therapeutic contribution to other diseases. For example, one focus is applied here to the roles of calprotectin in lung metastasis, which is implicated in psychiatric disorders and COVID-19 as shown by recent evidence.

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Inflammation and Metastasis
Language: en
Pages: 518
Authors: Yoshiro Maru
Categories: Medical
Type: BOOK - Published: 2021-10-06 - Publisher: Springer Nature

This book, now in a thoroughly revised and updated second edition, provides the latest information on cancer metastasis from the perspective of inflammation and presents new ideas on the complicated mechanisms of metastasis and potential therapeutic targets. Key features include discussion of mechanisms recently identified to be involved in the
Perioperative Inflammation as Triggering Origin of Metastasis Development
Language: en
Pages: 236
Authors: Michael W. Retsky, Romano Demicheli
Categories: Medical
Type: BOOK - Published: 2017-06-28 - Publisher: Springer

The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it
Oncostatin M Promotes Breast Cancer Metastasis
Language: en
Pages: 205
Authors: Ken Tawara
Categories: Breast
Type: BOOK - Published: 2017 - Publisher:

"Breast cancer is the most diagnosed cancer type in women and its resultant mortality is second only to lung cancer worldwide. While breast cancer is known to have many risk factors, inflammation remains an unquantifiable risk, and it can arise from obesity, depression, poor health, autoimmune diseases, and other conditions
Inflammation and Lung Cancer
Language: en
Pages: 212
Authors: Steven M. Dubinett
Categories: Medical
Type: BOOK - Published: 2015-06-24 - Publisher: Springer

In recent years there have been various discoveries connecting inflammation and lung cancer and clearly there is growing interest in this area of cancer research. The link between unresolved inflammation and cancer has been well established with estimates that 15% of cancer deaths are inflammation‐related. Evidence for this link includes
Crosstalk Between Mediators of Inflammation and the IGF Axis in Liver Metastasis
Language: en
Pages:
Authors: Shun Li
Categories: Medical
Type: BOOK - Published: 2011 - Publisher:

Liver metastases are a frequent and often fatal occurrence in cancer patients. A better understanding of the biology of liver metastasis is essential to improve survival statistics for these patients. Although the contribution of IGF-IR to malignancy has been recognized for over 2 decades, the role that the IGF axis